OINTMENT FORMULATION OF SNAKEHEAD FISH (Channa striata) EXTRACT AND KELULUT HONEY (Heterotrigona itama) WITH CMC-Na AS A BINDER
| Main Authors: | Titian Ratu, Nur Firdiena, Andrie, Mohamad, Taurina, Wintari |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN
, 2021
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| Online Access: |
http://jurnal.untan.ac.id/index.php/jmfarmasi/article/view/47173 http://jurnal.untan.ac.id/index.php/jmfarmasi/article/view/47173/75676589533 |
Daftar Isi:
- The ointment of snakehead fish extract and kelulut honey have been proven to be efficacious in the wound healing process. However, the ointment in previous studies underwent phase separation which indicated a lack stability of the preparation. In this study, CMC-Na was used as a binder to increase the consistency of the ointment by binding the water phase and preventing it from leaving the base. Methods: Variations in the concentration of CMC-Na used were 3% (F1); 4.5% (F2); and 6% (F3). The evaluation of the preparations was carried out in the form of organoleptic, homogeneity, dispersibility, adhesion, and protective power tests. The dispersion and adhesion power data were analyzed using the SPSS 21.0 program. Results: The ointment with CMC-Na was proven to have a denser consistency, so it was able to increase the stability of the ointment. The higher the CMC-Na concentration, the lower the dispersibility and the higher the adhesion of the preparation. F1 (CMC-Na 3%) had the highest average dispersive power of 5,09 cm. F3 (CMC-Na 6%) had the highest average adhesion of 1799 seconds. The SPSS analysis results showed that all formulas with CMC-Na had significant different dispersive and adhesion values from the control formula (? ? 0,05). Conclusions: Formula 1 (CMC-Na 3%) showed an ointment that meets the criteria with homogeneous preparation results, an average spreadability of 5-7 cm (5,09 cm), an average adhesion of not less than 4 seconds (1797,33 seconds), and has a good protective power.