CLINICOPATHOLOGY OF PUPPY WITH ENTERITIS AND MYOCARDITIS DUE TO CANINE PARVOVIRUS INFECTION: A CASE REPORT
| Main Authors: | Sewoyo, Palagan Senopati, Winaya, Ida Bagus Oka, Berata, I Ketut, Adi, Anak Agung Ayu Mirah, Dayanti, Marissa Divia, Grahadi, Rahmat, Takariyanti, Dzikri Nurma'rifah |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
The Faculty of Veterinary Medicine, Udayana University
, 2022
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| Online Access: |
https://ojs.unud.ac.id/index.php/buletinvet/article/view/85266 https://ojs.unud.ac.id/index.php/buletinvet/article/view/85266/47126 |
Daftar Isi:
- Canine parvovirus (CPV) disease is a highly contagious disease in dogs, spread by the fecal-oral or oronasal route. This virus has a tropism in cells that are active and rapidly dividing. The animal used as the case study is a three months old local mixed breed male puppy from Denpasar, Bali. The case puppy was found to be sick for four days. Clinical examination showed the puppy had anorexia, depression, vomiting, bloody diarrhea, cough, fever, and dehydration. Polymerase chain reaction (PCR) assay showed the puppy was positive for CPV infection. The results of the routine hematological examination showed that the CPV-infected puppy had normochromic normocytic anemia, leukocytopenia, monocytosis, and neutropenia. The gross pathological changes observed were cerebral meninges hyperemia, lung hyperemia, epicardium necrosis, liver congestion, renal medulla hyperemia, and small intestine hyperemia. Histopathologically the changes observed were necrotizing myocarditis, emphysematous bronchopneumonia, hemorrhagic and necrotizing hepatitis, splenic lymphoid follicle depletion, renal glomerular atrophy, hemorrhagic and necrotizing enteritis, and hydropic degeneration of the urinary bladder transitional epithelium. Based on clinical symptoms, hematological examination, gross pathology, histopathology, as well as isolation and identification of the virus, it can be concluded that the puppy was infected with enteritis and myocarditis CPV concurrently.
- Penyakit canine parvovirus (CPV) merupakan penyakit yang sangat kontagius pada anjing, menyebar melalui rute fekal-oral atau oronasal. Virus ini memiliki tropisme pada sel yang aktif dan cepat membelah. Hewan yang dijadikan studi kasus adalah seekor anjing ras lokal campuran jantan yang berumur tiga bulan, yang berasal dari Denpasar, Bali. Anjing kasus didapatkan dalam keadaan sakit selama empat hari. Pemeriksaan klinis menunjukkan anjing mengalami anoreksia, depresi, muntah-muntah, diare berdarah, batuk, demam, dan dehidrasi. Uji Polymerase Chain Reaction (PCR) menunjukkan anjing positif terhadap infeksi CPV. Hasil pemeriksaan hematologi rutin menunjukkan anjing mengalami anemia normositik normokromik, leukositopenia, monositosis dan neutropenia. Perubahan patologi anatomi yang teramati adalah hiperemia pada meningen otak, hiperemia paru-paru, nekrosis epikardium, kongesti pada hati, hiperemia medula ginjal, dan hiperemia pada usus halus. Secara histopatologi perubahan yang teramati adalah miokarditis nekrotikan, bronkopneumonia emfisematosa, hepatitis hemorrhagis et nekrotikan, deplesi folikel limfoid limpa, atrofi glomerulus ginjal, enteritis hemorrhagis et nekrotikan, dan degenerasi hidrofik epitel transisional vesica urinaria. Berdasarkan gejala klinis, pemeriksaan hematologi, perubahan patologi anatomi, histopatologi, serta isolasi dan identifikasi virus, maka dapat disimpulkan anjing kasus terinfeksi CPV bentuk enteritis dan miokarditis secara bersamaan.