HISTOPATHOLOGICAL CHANGES OF MICE LIVER THAT INDUCED BY ETHANOL EXTRACT OF ANT NEST TREE
| Main Authors: | Prasetyo, Yoga Eka, Merdana, I Made, Kardena, I Made, Sudira, I Wayan |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
The Faculty of Veterinary Medicine, Udayana University
, 2019
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| Online Access: |
https://ojs.unud.ac.id/index.php/buletinvet/article/view/34892 https://ojs.unud.ac.id/index.php/buletinvet/article/view/34892/28135 |
Daftar Isi:
- Anthill plants attracted many people as an alternative medicine because proven efficacious for treating tumor diseases, cancer, tuberculosis, stroke, coronary heart disease, diabetes mellitus, nosedleeds, ulcer, hemorrhoids, facilitate breastfeeding, increase stamina and sexual arousal. This study aimed to determine the effect of ethanol extract of the anthill plant to the mice liver histopathology. This study is an experimental laboratory. Twenty fourth male mice 10-12 weeks of age with a body weight of 25-35 grams were divided into 4 groups, each group consisting of 6 mice were given treatment that Control Group, Group I (doses 100mg/kg BW), Group II (doses 200mg/kg BW) and Group III (doses 300mg/kg BW) for 21 days. Hepatic histopathological changes were observed and assessed by histological damage in the form of infiltration of inflammatory cells, lipid degeneration and necrosis. Data were analyzed using statistical test of Kruskal-Wallis followed with Mann-Whitney Test (p<0.05). Kruskal-Wallis test result showed ethanol extract anthill very significant (p<0.01) effect on the incident of lipid degeneration, necrosis and infiltration of inflammatory cell of liver cells. Based on these result it can be concluded that the ethanol extract of anthill can cause histological changes in the liver of mice.
- Tanaman sarang semut (Myrmecodia pendans) banyak diminati masyarakat sebagai obat alternative karena terbukti berkhasiat untuk mengobati penyakit tumor, kanker, tuberculosis (TBC), stroke, jantung koroner, diabetes, mimisan, maag, asam urat, wasir, memperlancar asi, meningkatkan stamina dan gairah seksual. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol sarang semut terhadap gambaran histopatologi hepar mencit. Penelitian ini bersifat eksperimental laboratorik. Sebanyak 24 ekor mencit jantan umur 10-12 minggu dengan berat badan 25-35 gram dibagi menjadi 4 kelompok, masing-masing kelompok terdiri dari 6 ekor mencit yang diberi perlakuan yaitu Kelompok Kontrol (KK), Perlakuan I (dosis 100mg/kg BB), Perlakuan II (dosis 200mg/kg BB), dan Perlakuan III (dosis 300mg/kg BB) selama 21 hari. Perubahan histopatologi hepar diamati dan dinilai berdasarkan kerusakan histologi berupa infiltrasi sel radang, degenerasi melemak, serta nekrosis. Data yang diperoleh dianalisis dengan menggunakan uji statistik Kruskall-Wallis dilanjutkan dengan uji Mann Whitney. Hasil uji Kruskall-Wallis menunjukkan pemberian ekstrak etanol sarang semut berpengaruh sangat nyata (p<0,01) terhadap timbulnya degenerasi melemak, nekrosis, dan infiltrasi sel radang pada sel hepar. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa ekstrak etanol sarang semut dapat menyebabkan perubahan histologi hepar mencit.