AGING AND STEM CELL THERAPY: AMPK AS AN APPLICABLE PHARMACOLOGICAL TARGET FOR REJUVENATION OF AGED STEM CELLS AND ACHIEVING HIGHER EFFICACY IN STEM CELL THERAPY
| Main Authors: | Mohammadhossein Khorraminejad-Shirazi, Mohammad Farahmandnia, Bahareh Kardeh, Alireza Estedlal, Sina Kardeh, Ahmad Monabati |
|---|---|
| Format: | Book |
| Bahasa: | eng |
| Terbitan: |
Elsevier
, 2018
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| Subjects: | |
| Online Access: |
http://www.repository.ikestmp.ac.id//index.php?p=show_detail&id=18 http://www.repository.ikestmp.ac.id//lib/phpthumb/phpThumb.php?src=../../images/docs/cover.jpg.jpg |
Daftar Isi:
- In recent years, tissue regeneration has become a promising field for developing stem cellbased transplantation therapies for human patients. Adult stem cells are affected by the sameaging mechanisms that involve somatic cells. One of the mechanisms involved in cellular agingis hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and disruption of 50adenosine monophosphate-activated protein kinase (AMPK). Aging of stem cells results in theirimpaired regenerative capacity and depletion of stem cell pools in adult tissue, which results inlower efficacy of stem cell therapy. By utilizing an effective therapeutic intervention for agedstem cells, stem cell therapy can become more promising for future application. mTORC1 inhibition is a practical approach to preserve the stem cell pool. In this article, we review thedynamic interaction between sirtuin (silent mating type information regulation 2 homolog) 1,AMPK, and mTORC1. We propose that using AMPK activators such as 5-aminoimidazole-4-carboxamide ribonucleotide, A769662, metformin, and oxidized nicotinamide adenine dinucleotide (NAD+) are practical ways to be employed for achieving better optimized results instem cell-based transplantation therapies.
- STIKes Muhammadiyah Palembang