The Potency Of Extract Tegining Ganang Leaf (Cassia Planisiqua Burm.f.) As Analgesic On Mice (Mus musculus L.) By Chemical And Hot Plate Induction Method
| Main Authors: | Sianturi, Sister; Institut Sians dan Teknologi Nasional, Febriani, Amelia; Institut Sians dan Teknologi Nasional, Syariifatul, Rahmi; Institut Sians dan Teknologi Nasional, Satrana, Desy; Institut Sians dan Teknologi Nasional |
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| Other Authors: | Institut Sains dan Teknologi Nasional |
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Pusat Penelitian dan Pengembangan Perkebunan
, 2019
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| Subjects: | |
| Online Access: |
http://ejurnal.litbang.pertanian.go.id/index.php/bultro/article/view/9570 http://ejurnal.litbang.pertanian.go.id/index.php/bultro/article/view/9570/8562 http://ejurnal.litbang.pertanian.go.id/index.php/bultro/article/downloadSuppFile/9570/1039 |
Daftar Isi:
- Tegining ganang is a plant found in Lombok has potential to overcome various diseases but not many have examined it in laboratory because local people still consider this plant as wild plants. Researchers wanted to prove in vivo the analgesic potential of this plant extract by testing the extract in experimental animals male mice using two methods, namely chemical induction and hot-plate induction. The use of these two methods to prove the effectiveness of these plants both as central analgesics and peripheral analgesics. The treatment group was divided into 200 mg / kg BW, 400 mg / kg BB, 800 mg / Kg BB mice. Based on the research results obtained that the extract is very potential as an analgesic when compared with controls. Both with chemical induction and thermal induction indicated good effectiveness for use as candidates for analgesic drugs. In the chemical induction analgesic test, the effectiveness percentage was 98.90% compared to the positive control, and the induction analgesic test obtained an effectiveness percentage of 123.9% compared to the positive control.
- Tegining ganang (Cassia planisiliqua) is an indigenous plant of Lombok, West Nusa Tenggara which has potentials to treat various diseases. Previous research showed that the plant has analgesic activity, but the results were still less satisfactory due to the low analgesic effectiveness (<50 %). This study aimed to examine the analgesic potential of tegining ganang leaf extract through chemical induction and hot plate induction methods. In vivo testing was conducted on male mice using those two methods to evaluate plant effectiveness as both a central and peripheral analgesic. Tegining ganang leaves collected from the village of Peresak, West Lombok, West Nusa Tenggara Province, were extracted in ethanol 70%. The treatments were extract dosages, viz. 200, 400, 800 mg.kg-1 body weight (BW) of mice. The positive control treatments for the chemical induction and hot plate induction methods were Acetosal and Tramadol, respectively. Meanwhile, the negative control treatment was Na CMC at 0.5%. The analgesic effectiveness of the extract in both chemical and hot plate induction methods was 50 %. The optimum effectiveness for chemical induction was at 800 mg.kg-1 body weight, whereas for hot plate induction was at 200 mg.kg-1 body weight. The results indicated that the ethanol extract of tegining ganang leaves was potential to be developed as an analgesic material.