Similarity Check Antihypercholesterol Activity of Costus Speciosus Water Extract
| Main Authors: | Susanti, Hari, Wahyuono, Subagus, Puspita Sari, Ika, Asmah Susidarti, Ratna |
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| Format: | Lainnya NonPeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmaceutical Sciences, Chulalongkorn University
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| Subjects: | |
| Online Access: |
http://eprints.uad.ac.id/20678/1/Antihypercholesterol_activity_of_Costus__speciosus.pdf http://eprints.uad.ac.id/20678/ http://www.tjps.pharm.chula.ac.th/ojs/index.php/tjps/article/view/270/180 |
Daftar Isi:
- Introduction: Hypercholesterolemia is one of the causes of cardiovascular disease. Costus speciosus (CS) is known empirically as an antihypercholesterol remedy. Material and Method: This study was conducted to determine the effect of water extract of CS on cholesterol blood serum level of rat induced-propylthiouracil (PTU). The antihypercholesterol activity performed on male Wistar rats which induced 0.01% PTU (mixed in drinking water, 14 day-induction) was followed by the administration of CS for 14 days. The animals were randomly divided into seven groups: Solvent control (carboxylmethylcellulose 0.5% w/v in water), positive control (simvastatin at dose 7.2 mg/kg BW), negative control (water), CS extract 50, 100, and 200 mg/kg, and normal control. The cholesterol levels were measured at day 0th, 14th, and 28th. Result and Conclusion: Results showed that administration of CS extract 200 mg/kg can reduce the total serum cholesterol equal to simvastatin 7.2 mg/kg.