The Effectiveness of Sunkist Orange Peel (Citrus sinensis (L.) Osbeck) Ethanol Extract on Blood Sugar Level of Streptozotocin Induced Wistar Rat (Rattus norvegicus) with Hypercholesterolemia: UJI EFEKTIVITAS EKSTRAK ETANOL KULIT JERUK SUNKIST (Citrus sinensis (L.) Osbeck) TERHADAP KADAR GULA DARAH TIKUS WISTAR (Rattus norvegicus) DENGAN HIPERKOLESTEROLEMIA YANG DI INDUKSI STREPTOZOTOCIN
| Main Authors: | Depari, Sania Angelisa F, Rambe, Daffa Jihan Azmi , Meilando, Rifki, Lisya, Cut, Mutia, Maya Sari , Lubis, Yolanda Eliza Putri |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Universitas Jambi
, 2021
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| Subjects: | |
| Online Access: |
http://online-journal.unja.ac.id/biospecies/article/view/11250 http://online-journal.unja.ac.id/biospecies/article/view/11250/10510 |
Daftar Isi:
- The Condition of high blood sugar levels in people with diabetets appears to trigger an increase in LDL and decrease HDL level where in people with diabetes the energy obtained by the body comes from the decomposition of fat and protein metabolism.”Sunkist orange peel (Citrus sinensis (L.) Osbeck) is reported to have antidiabetic, anti-hypercholesterolemia, anti-inflammatory and antioxidant activities. This study aims to find out the effectiveness of Sunkist orange peel ethanol extract (Citrus sinensis (L.) Osbeck) on blood sugar levels at doses of 500, 750 and 1000 mg/kgBB. This study used the True Experimental Pre-Test and Post-Test Control Group as research design where sunkist orange peel was extracted by maceration method and was given orally for 14 days to streptozotocin induced wistar rat with hypercholesterolemia. Statistical test results showed that ethanol extract of Sunkist orange peel was able to lower blood sugar levels and cholesterol levels of h streptozotocin induced wistar rat with hypercholesterolemia (p<0.05). The most effective dose of Sunkist orange peel ethanol extract in lowering blood sugar levels and cholesterol levels of streptozotocin induced wistar rat with hypercholesterolemia is 1000mg/kgBB.
- Kondisi kadar gula darah yang tinggi pada penderita diabetes ternyata memicu peningkatan LDL dan penurunan HDL dimana pada orang dengan diabetes”energi yang didapatkan tubuh berasal dari penguraian lemak dan metabolisme protein. Kulit jeruk Sunkist (Citrus sinensis (L.) Osbeck) dilaporkan memiliki aktivitas antidiabetik, antihiperkolesterolemia, antiinflamasi serta antioksidan . Penelitian ini bertujuan untuk mengetahui efektivitas dari ekstrak etanol kulit jeruk Sunkist (Citrus sinensis (L.) Osbeck) terhadap kadar gula darah pada dosis 500, 750 dan 1000 mg/kgBB. Penelitian ini menggunakan rancangan penelitian True Experimental Pre-Test and Post-Test Control Group Design dimana kulit jeruk Sunkist yang diekstraksi dengan metode maserasi diberikan secara oral selama 14 hari pada tikus wistar hiperkolesterolemia yang diinduksi streptozotocin. Hasil pengujian statistik menunjukkan bahwa ekstrak etanol kulit jeruk Sunkist”mampu menurunkan kadar gula darah dan kadar kolesterol tikus wistar hiperkolesterolemia yang diinduksi streptozotocin (p<0,05). Dosis ekstrak etanol kulit jeruk Sunkist yang paling efektif dalam menurunkan kadar gula darah dan kadar kolesterol tikus wistar hiperkolesterolemia yang”diinduksi streptozotocin adalah 1000mg/kgBB.