Uji Aktivitas Antidiabetes dari Ekstrak Metanol Buah Kiwi (Actinidia deliciosa) melalui Penghambatan Aktivitas α-Glukosidase: Antidiabetic Activity of Kiwi Fruit (Actinidia deliciosa) Extract through Inhibition of α-Glucosidase Activity
| Main Authors: | Meila, Okpri, Noraini, Noraini |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Universitas Tadulako
, 2017
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| Online Access: |
https://bestjournal.untad.ac.id/index.php/Galenika/article/view/8814 https://bestjournal.untad.ac.id/index.php/Galenika/article/view/8814/7320 |
Daftar Isi:
- Diabetes melitus (DM) is defined as a chronic metabolic disease or disorder with multiple etiologies characterized by high blood sugar levels. One way to treat diabetes mellitus is inhibiting the α-glucosidase enzyme. This study aims to determine the inhibition of α-glucosidase of methanol extract of kiwi fruit (Actinidia deliciosa) . Kiwi fruit (Actinidia deliciosa) contains saponins characterized by the formation of foam, positive flavonoid characterized by the formation of a yellow color (orange) and positive alkaloid which is characterized by brown color in wagner test. The inhibition activity test of α-glucosidase enzyme was performed by using spectrophotometric method. The results of the inhibition activity test of α-glucosidase enzyme in acarbose showed the value of 13,672 mg/L, while the methanol extract of kiwi fruit showed IC50 value of 7.219 mg/L. It demonstrated that themethanol extract of kiwi fruit has the inhibition activity greater than acarbose.