SEROEPIDEMIOLOGIC CORRELATIONS IN MALARIA
| Main Author: | Baird, Kevin; Division of Parasitology, US Namru #2 Detachment, Jakarta, Indonesia |
|---|---|
| Other Authors: | BADAN LITBANGKES KEMENKES |
| Format: | application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Badan Penelitian dan Pengembangan Kesehatan
, 2012
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| Subjects: | |
| Online Access: |
http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/661 |
Daftar Isi:
- Serologic measurements of humoral immunity have been used to estimate malaria transmission in endemic areas. The usual methods employ enzyme linked immunosorbent assays (ELISA) and immunofluores-cent antibody tests of a wide variety of malaria antigens. In theory, higher levels of antibody reflect higher levels of exposure to malaria antigen i.e., disease. However, one must carefully consider variables such as endemicity, species of malaria present, age of the group examined, and the antigent/test array selected. Without doing so, it is easy to draw erroneous conclusions. This presentation provides guidelines to selecting a test and antigen appropriate for deriving given epidemiologic conclusions from serologic surveys. Also, recent work on DNA probes of malaria and serum markers of cell-mediated immunity is described in context of epidemiologic measures of malaria transmission.