HUBUNGAN SENSISTIVITAS PLASMODIUM FALCIPARUM TERHADAP KOMBINASI PIRIMETAMIN/SULFADOKSIN DAN KLOROKUIN SECARA IN VITRO
| Main Authors: | Ompusunggu, Sahat; Pusat Penelitian Penyakit Menular, Badan Penelitian dan Pengembangan Kesehatan, Jakarta, Arbani, R. P.; Subdit malaria, Ditjen Pemberantasan Penyakit Menular dan Penyehatan Lingkungan Pemukiman, Jakarta, Marwoto, Harijani A.; Pusat Penelitian Penyakit Menular, Badan Penelitian dan Pengembangan Kesehatan, Jakarta, E., Sekar Tuti; Pusat Penelitian Penyakit Menular, Badan Penelitian dan Pengembangan Kesehatan, Jakarta, Renny, Marvel; Pusat Penelitian Penyakit Menular, Badan Penelitian dan Pengembangan Kesehatan, Jakarta |
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| Other Authors: | BADAN LITBANGKES KEMENKES |
| Format: | application/pdf eJournal |
| Bahasa: | ind |
| Terbitan: |
Badan Penelitian dan Pengembangan Kesehatan
, 2012
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| Subjects: | |
| Online Access: |
http://ejournal.litbang.depkes.go.id/index.php/BPK/article/view/400 |
Daftar Isi:
- An in vitro sensitivity test was conducted to study the sensitivity of Plasmodium falciparum against chloroquine and pyrimethamine/sulphadoxine combination. The relationship between sensitivity of the parasite to the two drugs was also studied. A total of 72 patients from five localities were examined during 1984-1985. Test against chloroquine was conducted according to WHO method, while against pyrimethamine/sulphadoxine combination, a modified method of Nguyen Dinh and Payne and Eastham and Rieckmann was used. The results showed that there is no relationship between the sensitivity of P. falciparum against pyrimethamine/ sulphadoxine combination and chloroquine. It can be concluded that in case of chloroquine resistant P. falciparum, pyrimethamine/sulphadoxine combination could be applied as an alternative chemotherapy.