Pengaruh Pemberian Etanol Secara Kronik Terhadap Jumlah Sel Piramidal di Ca1 Hippocampus Tikus (Rattus Norvegicus) Remaja
| Main Authors: | Narwanto, Muh. Ihwan, Aswin, Soedjono, Mustafa, Mustafa |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Anatomi Indonesia
, 2012
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| Online Access: |
https://journal.ugm.ac.id/jai/article/view/1143 https://journal.ugm.ac.id/jai/article/view/1143/951 |
Daftar Isi:
- Chronic ethanol administrationmay causemorphological changes in the hippocampus. The aimof this study is toinvestigate the changes of the number of pyramidal cell in CA1 hippocampus of adolescent rats after chronicethanol administration.The subjects of this study were 25 adolescent (30 days of age) male rats (Rattus norvegicus) divided into 5groups : control without treatment (K1), control with treatment (K2), treatment 1 (P1), treatment 2 (P2) andtreatment 3 (P3)group. Each group consist of 5 rats. K2 group were given physiological saline, P1, P2, and P3group were given ethanol with doses 1 g/kg/day, 2 g/kg/day, and 3 g/kg/day respectively for 30 days byintraperitoneal injection.After 12 days free from ethanol, the rats were killed and the brains were removed tomake paraffin block andCresyl violet stain. The number of pyramidal cells ofCA1 were counted per field of viewat 400xmagnification.The results of this study showed that chronic ethanol administration at adolescent age causedmorphologicalchanges in hippocampus. The number of pyramidal cells ofCA1 in each group:K1=55,03±2,87;K2=54,38±2,21;P1=49,98±2,16;P2=51,82±4,71;P3=46,28±3,29 (p<0,05). It is concluded that in rats, chronic ethanol administrationat adolescent age caused decreasing number of pyramidal cells of CA1 hippocampus.