Hubungan antara tebal lamina pyramidalis CA1 hippocampus dengan memori kerja pada tikus (Rattus norvegicus) pascastres kronik
| Main Authors: | Wiyono, Nanang, Aswin, Soedjono, Harijadi, Harijadi |
|---|---|
| Format: | Article info application/pdf Journal |
| Bahasa: | eng |
| Terbitan: |
Jurnal Anatomi Indonesia
, 2007
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| Online Access: |
https://journal.ugm.ac.id/jai/article/view/1129 https://journal.ugm.ac.id/jai/article/view/1129/944 |
Daftar Isi:
- Chronic stress may cause morphological changes in the hippocampus following by deficit in hippocampalfunction including the impairment ofworkingmemory.The aimof this study is to investigate the changes the thickness of pyramidal layer CA1 hippocampus and it’scorrelation with working memory of the rats after chronic stress.The subjects of this study were 10male rats (Rattus norvegicus) divided into control group (C) and treatmentgroup (T), each group consist of 5 rats.Workingmemory performancewas tested for each group by using 8-armradial maze for 12 days. Working memory measured by error type A. After tested, T rats group were givenchronic stress procedure with electrical footshock of 60 volt for 10 seconds with 15 seconds interval for 15minutes each day for 25 days.After chronic stress, the workingmemory of T and C group were tested again byusing 8-armradialmaze for 12 days.At the end, the ratswere killed and the brainwas removed tomake paraffinblocks of CA1 hippocampus to stain with hematoxylin. The thickness of pyramidal layer CA1 hippocampusmeasured undermicroscope at 400xmagnification.The results of this study showed that chronic stress caused decreasing of workingmemory of the rats showedby error typeAforT group are higher thanCgroup (p<0.05).Chronic stress also caused morphological changesin hippocampus showed by the thickness of pyramidal layer ofCA1 hippocampus in T group are smaller than Cgroup (p<0.05). With correlation product moment test there are positif correlation between the thickness ofpyramidal layer of CA1 hippocampus with workingmemory of the rats after chronic stress (p<0.05).The study concludes that chronic stress caused decreasing of workingmemory of the rats and the thickness ofpyramidal layer of CA1 hippocampus. It is concerned there are positive correlation between the thickness ofpyramidal layer of CA1 hippocampus with workingmemory of the rats after chronic stress.