Pengaruh tenotomi terhadap perkembangan musculus soleus dan musculus extensor digitorum longus Rattus norvegicus yang diberi T3 (triiodotironin)
| Main Author: | Prakosa, Djoko |
|---|---|
| Format: | Article info Journal |
| Bahasa: | ind |
| Terbitan: |
Jurnal Anatomi Indonesia
, 2007
|
| Online Access: |
https://journal.ugm.ac.id/jai/article/view/1127 |
Daftar Isi:
- Muscle fiber type can change because of the change in the functional need and other signs.Motoneuron activitypattern of the locomotor systemchanges during the development.During this development type I fibers percentageincreases in the slowmuscle, but decreases in the fastmuscle. Treatment with T3 decreases type I fiberspercentage without influencing the muscle fibers developmental stages. Thus, it is thought that motoneuroninvolves in the mechanism of action of T3on the muscle fibers. Tenotomy that inactivates the muscle withoutinterrupting the flow of neurotrophic factor to themuscle fibers, can also changesmuscle fibers type. The aimof this experiment is to revealed the interaction between the effect of tenotomy and T3 treatment on the developmentof rats SOL (soleus) and EDL (extensor digitorumlongus)muscles. Thus, the role ofmotoneuron on themechanismof action of T3 can be known.Seven, 17 and 23-day-oldmale rats are divided into two groups.GroupI was injectedwithT3 400μg/kgBB intraperitoneally every other day.Group IIwas injectedwith physiologic salinesolution in the same way as group I. In the beginning of the experiment SOL and EDL in one limb of all rats istenotomized. Three, 5 or 7 week after the treatment themuscles were examined. In both groups, size, weightand fibers type I percentage in the tenotomized limb are significantly lower than the untenotomized. Therewereonly slight changes in the EDL.Thus, the effect of tenotomy and T3 treatment are strengthening each other. It isconcluded thatmotoneuron has a role in themechanismof action of T3 on themuscle fibers. The role is thoughtthrough its effect on neutrotrophic substance