Daftar Isi: In-vitro studies on antioxidant and antidiabetic potential of Sesoot (Garcinia picrorrhiza Miq.) fruit ethanolic extract from Indonesia

Main Authors:	Utami, Sri; Faculty of Medicine, YARSI University, Laksono, Sonny Pamuji; Faculty of Medicine, YARSI University, Sachrowardi, Qomariyah Romadhiyani; Faculty of Medicine, YARSI University, Mustaqimah, Dewi Nurul; Faculty of Medicine, YARSI University, Endrini, Susi; Faculty of Medicine, YARSI University, Damayanti, Ndaru Andri; Faculty of Medicine, YARSI University, Nafik, Said; Directorate General of Intellectual Property, Ministry of Law and Human Rights, Jl. H.R. Rasuna Said, Kuningan, Jakarta Selatan. Indonesia., Arrahmani, Betharie Cendera; Faculty of Business and Engineering, University of Applied Sciences Würzburg-Schweinfurt, Ignaz-Schön Str 11, 97421 Schweinfurt, Germany., Kusuma, Hanna Sari Widya; Aretha Medika Utama, Biomolecular and Biomedical Research Center, Widowati, Wahyu; Faculty of Medicine, Maranatha Christian University
Other Authors:	YARSI University and Aretha Medika Utama Biomolecular and Biomedical Research Center, Bandung, Indonesia
Format:	Article info application/pdf eJournal
Bahasa:	eng
Terbitan:	Universitas Ahmad Dahlan , 2021
Subjects:	antidiabetic antioxidant Garcinia picrorrhiza xanthone
Online Access:	http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/20110 http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/20110/pdf_198 http://journal.uad.ac.id/index.php/PHARMACIANA/article/downloadSuppFile/20110/3590

Daftar Isi:

Diabetes mellitus (DM) is a disease that can be identified by high levels of blood glucose. Garcinia plants have been widely used for many traditional medicines as antioxidant, anticancer, antidiabetics, and antiinflammation. The antioxidant and antidiabetic activities of (Garcinia picrorrhiza Miq.) or sesoot fruit extract were evaluated in this study and compared with xanthone. The antioxidant and antidiabetic of ethanolic ripe sesoot (G. picrorrhiza Miq.) fruit extract (GpKar) was evaluated by (ABTS) reducing activity, α-glucosidase, β-glucosidase, and α-amylase inhibitor activity. GpKar showed higher ABTS-reducing activity (IC50 = 49.30 μg/mL) than xanthone (IC50 = 404.30 μg/mL). GpKar showed IC50 = 109.32 μg/mL for α-glucosidase inhibitory activity, while xanthones had a better activity (IC50 = 33.97 μg/mL). GpKar also showed lower α-amylase inhibitory activity and β-glucosidase (IC50 = 126.01 and 9432.09 μg/mL) compared to xanthone (IC50 = 44.32 and 405.03 μg/mL, respectively). The compounds of GpKar are proven to have antioxidant and antidiabetic activities. Therefore, it will be industrially relevant to develop a natural medicine for decreasing DM risk, thus evaluating the antioxidant and antidiabetic effect of G. picrorrhiza by a pre-clinic study is needed.