Anti-inflammatory activity of essential oil of clove (Syzygium aromaticum) in O/W and W/O Creams
| Main Authors: | Sugihartini, Nining; Faculty of Pharmacy, Ahmad Dahlan University, Lestari, Gina; Akademi Farmasi Al-Fatah Bengkulu, Yuliani, Sapto; Fakultas Farmasi Universitas Ahmad Dahlan |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Universitas Ahmad Dahlan
, 2019
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| Subjects: | |
| Online Access: |
http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/10023 http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/10023/pdf_110 http://journal.uad.ac.id/index.php/PHARMACIANA/article/downloadSuppFile/10023/2007 |
Daftar Isi:
- Previous studies have shown that the formulations of clove bud essential oil (CBEO) with a concentration of 5% in O/W cream and 2.5% in W/O cream have anti-inflammatory properties. The formulations are developed by adding enhancers, namely oleic acid and propylene glycol. The optimum compositions of oleic acid and propylene glycol are 50%:50% in W/O cream and 30%:70% in O/W cream. This study aimed to determine the effects of different compositions of creams on their anti-inflammatory activities. The creams were evaluated for their anti-inflammatory properties using mice with croton oil-induced inflammatory. The mice were sacrificed, and the back skin was removed to make histopathologic preparations at the end of the three-day inflammatory induction to obtain data of epidermal thickness and the number of cells with COX-2 expression. The results showed that the addition of oleic acid and propylene glycol as enhancers increased the anti-inflammatory activity of both O/W and W/O creams. Since the O/W cream decreased the thickness of the epidermis and the number of cells with COX-2 expression more than the W/O cream, the formulation of CBEO in O/W cream is concluded as a better anti-inflammatory than that of W/O cream.