Structural, Antioxidant and Antivarial Studies of C-3-nitrophenyl CALIX[4]resorcinarene
| Main Authors: | M Yamin, Bohari; School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia, M Abosadiya, Hamza; School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia, Aisah Hasbullah, Siti; School of Chemical Sciences, Universiti Kebangsaan Malaysia, Bangi, 43600, Selangor Malaysia, Jumina, Jumina; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University, Indonesia |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
International Journal on Advanced Science, Engineering and Information Technology
, 2014
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| Subjects: | |
| Online Access: |
http://insightsociety.org/ojaseit/index.php/ijaseit/article/view/383 http://insightsociety.org/ojaseit/index.php/ijaseit/article/view/383/401 |
Daftar Isi:
- The calix[4]arene derivative C-3-nitrophenylcalix[4]resorcinarene was synthesized by using one-pot reaction of resorcinol with 3-nitrobenzaldehyde in the presence of concentrated HCl. The compound was characterized by IR, 1H and 13C NMR spectroscopy. X-ray crystallographic study showed that this compound crystallized in a triclinic system with space group of Pī and the unit cell dimensions, a = 10.6143(3) Å ,b = 13.6262(4) Å, c = 14.7971(5) Å, α = 102.813(3)°, β = 110.917(3)°, γ = 90.885(2)°. V= 1938.78(11) Å3 and Z =2. The biological Studies were also investigated. It has a stromg antioxidant property and high antiviral activity against HSV-1 . Cytotoxicity testing on Vero cells showed that it is non-toxic, with a CC50 of more than 0.4 mg/mL. Moderate antibacterial activity.