Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung
| Main Authors: | Rezano, Andri, Pan, Chen En, Istiqomah, Afrida Aizzatun, Zada, Almira |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
International Journal of Integrated Health Sciences
, 2018
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| Subjects: | |
| Online Access: |
http://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1374 http://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1374/1203 http://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1374/873 |
Daftar Isi:
- Objective: To analyze the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer. Methods: A retrospective observational study on the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer was conducted. This study included twenty-five female patients with invasive breast cancer who met the inclusion criteria. Parameters analyzed were age, tumor size, and immunohistochemical expression of Ki-67. Size of the tumor at pre- and post-neoadjuvant chemotherapy were obtained in cm3 and compared between 3 groups of Ki-67 expression levels. One way ANOVA was used to perform the statistical analysis. Results: A significant difference in changes of tumor size for Ki-67 level >20% compared to <14% and 14–20% was seen. Based on the result, neoadjuvant chemotherapy was proven to have similar effects in patients with Ki-67 expression of <14% and 14–20% but less effective in patients with Ki-67 expression of >20%. Conclusions: Low to modest expression of Ki-67 was a better biomarker to predict the response of neoadjuvant chemotherapy in patients with invasive breast cancer compared to high expression of Ki-67. However, the cut-off value of 20% could be ideal to predict the outcome of neoadjuvant chemotherapy in patients with invasive breast cancer. DOI: 10.15850/ijihs.v6n2.1374