ENDOTHELIN-1, NITRIC OXIDE, AND RATIO OF ET-1/NO IN ERECTILE DYSFUNCTION
| Main Author: | Sinrang, Andi Wardihan |
|---|---|
| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Indonesian Urological Association
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| Subjects: | |
| Online Access: |
http://juri.urologi.or.id/index.php/juri/article/view/169 http://juri.urologi.or.id/index.php/juri/article/view/169/113 |
Daftar Isi:
- Objective: The aim of this study was to observe the level of Endothelin-1 (ET-1), Nitric oxide (NO), and the ratio of ET- 1/NO in Erectile dysfunction (ED) and normal subjects. Material & method: This case-control study was carried out in Makassar with subjects recruited from outpatient clinic at Wahidin Sudirohusodo Hospital and divided into 2 groups (56 subjects DE and 34 subjects normal). ET-1 and NO plasma were measured by ELISA technique according to protocol. Results: The data showed that mean value of ET-1 in erectile dysfunction subjects was significantly higher (p < 0,05), while NO was significantly lower (p < 0,05) in DE groups compared to normal groups. The ratio of ET-1/NO was also significantly different between both groups. Conclusion: We concluded that level of plasma ET-1, plasma NO, and the ET-1/NO ratio are important factors involved in ED pathomechanism