FAST DISSOLVING TABLETS OF PIMOZIDE: DESIGN, OPTIMIZATION AND INVITRO CHARACTERIZATION
| Main Authors: | Kamisetti, Raja Rajeswari; 1Vishnu Institute of Pharmaceutical Education and Research, (Affiliated to Jawaharlal Nehru Tech. University, Hyderabad), Narsapur, Medak, Hyderabad 502 313., Mekala, Moses; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014., Muvvala, Sudhakar; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014., Penmatsa, Durga Bhavani; Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad. 500 014. |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2015
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/785 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/785/655 |
Daftar Isi:
- As precision of dosing and patient compliance become an important prerequisite for a long-term treatment of Tourette’s syndrome there is a need to develop formulation for this drug, which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and patient’s acceptability. The present work was undertaken with a view to develop a fast dissolving tablets of Pimozide using Kyron T-314 as super-disintegrant along with Avicel PH 102 as diluent by response surface method using direct compression. Drug-excipient compatibility studies were confirmed by FTIR Spectroscopy. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time and uniformity of content and invitro dissolution. Based on evaluating parameters, formulation prepared by using 4.5% Kyron T-314 with 11.5% Avicel PH-102 was selected as optimized formulation and Formulation (F3) had disintegration time of 7.63±0.25s. and percentage cumulative drug release of 81.60 after 10min. The formulations were further studied and confirmed for their stability. Hence it was concluded that direct compression using Kyron T-314 superdisintegrant and Avicel PH 102 was simple and economic technique which can be used for formulation of fast dissolving tablets of Pimozide.Key word: Pimozide, Tourette’s syndrome, fast dissolving tablets, Kyron T 314, direct compression