ANTIHEPATOTOXIC ACTIVITY OF TWO NEW QUERCETIN DERIVATIVES IN CARBON TETRACHLORIDE INDUCED HEPATOXICITY IN RATS
| Main Author: | Khan, Shah Alam; Antihepatotoxic Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy Jamia Hamdard, New Delhi- 110062, India |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/64 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/64/46 |
Daftar Isi:
- Quercetin, a bioflavonol is widely found in nature andpossesses diverse pharmacological properties. A heterocyclic 1,4dioxane nucleus was incorporated in Quercetin structure to obtaintwo structural analogues of silybin. The aim of the study was toantihepatotoxic potential of Quercetin derivatives containing 1,4dioxane heterocyclic ring in Carbon tetrachloride (CCl4) inducedhepatotoxicity in female Wistar Albino rats. Two Quercetinderivatives (QD) were synthesized by reported method. QD wereadministered orally at dose of 10 mg/kg, once daily for 7 days toWistar Albino rats. A single dose of CCl4 (1mL/kg) was used forinducing liver damage. Antihepatotoxic activity was evaluated bymeasuring levels of total proteins (TP), total albumin (TA), alkalinephosphatase (ALKP) and liver enzymes such as serum glutamateoxaloacetate (SGOT) and serum glutamate pyruvate transaminase(SGPT).QD exhibited potent antihepatotoxic activity with respect tostandard drug silybon-70. However, it was observed that theQuercetin derivative having –CH2OH group in the dioxane ringexhibitedbetter activity in comparision to unsubstituted 1,4dixoane ring derivative.The exact mechanism by which QD protectsthe liver is unknown however the observed effects could beattributed to presence of 1,4 dioxane ring and due to thesignificant antioxidant activity of Quercetin flavone.Key words: Antihepatotoxic activity, Quercetin; Silymarin, 1,4 dioxanering, CCl4