FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF DOMPERIDONE MALEATE
| Main Author: | Dixit, Yuwaraj Dilipsingh; Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, (MS), India |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/63 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/63/45 |
Daftar Isi:
- The objective of the present study was to develop andevaluate mucoadhesive dosage form of Domperidone maleate. It isan antiemetic synthetic benzimidazole compound that acts as adopamine D2 receptor antagonist. Mucoadhesive Domperidonemaleate tablet formulation was prepared by direct compressionmethod. The formulation F3 containing (Carbopol 940 + sodiumalginate) was found to be best among all the formulation batchesbecause of its consistent release rate for 7 h and extent of drugrelease was 94.44%. Graphical treatment of the formulation F3 toHiguchi’s equation showed that the drug release was diffusionmediated. In-vitro permeability study for formulation F3 for 7 h hadshown 76.69% drug release. FTIR studies showed no evidence oninteraction between drug and polymers.Key words: Domperidone maleate, Mucoadhesive tablet, antiemetic