Modeling of p-aminophenol compounds as analgesic antiinflammatory based on biologic activity and structure relationship
| Main Authors: | ., Pudjono; Faculty of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia, Susilowati, Sri Sutji; Pharmacy and Medicine, FKIK Universitas Jendral Sudirman. Jl. Dr. Soeparno, Karangwangkal, Purwokerto, 53122, ., Rehana; Pharmacy and Medicine, FKIK Universitas Jendral Sudirman. Jl. Dr. Soeparno, Karangwangkal, Purwokerto, 53122 |
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| Format: | Article info eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2011
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/605 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/605/480 |
Daftar Isi:
- This research aim was to find out the new compounds model of paminophenol derivates which have analgesic anti-inflammatory activity based on structure and biologic activity relationship analysis by computation methods. Seventeen compounds of p-aminophenol derivates were used in this research, and six compounds known its analgesic-antiinflammatory activity were used for determine QSAR equation model. This research’s result was a QSAR equation that can be using for synthesis the higher activity new compound of paminophenol. Key words : p-aminophenol compounds, analgesic anti-inflammatory activity, structure and activity relationship, QSAR equation, computation methods