Cytotoxicity of oleandrin isolated from the leaves of Nerium indicum Mill. on several human cancer cell lines
| Main Authors: | Wahyuningsih, Mae S.H.; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, indonesia., Mubarika, Sofia; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, indonesia., Bolhuis, R.L.M.; Erasmus Medical Center, Rotterdam, the Netherlands, Nooter, K.; Erasmus Medical Center, Rotterdam, the Netherlands, Gandjar, Ibnu G.; Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia., Wahyuono, Subagus; Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia. |
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| Format: | Article info eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2005
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/563 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/563/440 |
Daftar Isi:
- Finding anticancer drugs from natural resources still proceeds. Oleandrin isolated from Nerium indicum Mill. inhibited the growth of mieloma cell line in vitro better than that of vincristine sulphate. This study was aimed to determine the cytotoxic effect of oleandrin on various human cancer cell lines. Cytotoxic test of oleandrin on seven human cancer cell lines was done by SRB-method. The analysis was conducted by comparing the ID50 of oleandrin with that of doxorubicin and cisplatin as positive controls. This result indicated that oleandrin possessed the best cytotoxic effect on breast cancer (MCF7) with ID50 at 8.85 nM. Keywords : Oleandrin, cytotoxicity, human cancer cells, ID50