Characterization and dissolution studies of Furosemide solid dispersions using polyethylene glycol (PEG), talc and PEG-talc as dispersion carriers
| Main Authors: | Syukri, Yandi; Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Yogyakarta, Indonesia., Rizayulianty, Diny; Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Yogyakarta, Indonesia., Darty, Yuni; Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Yogyakarta, Indonesia. |
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| Format: | Article info eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2005
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/554 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/554/431 |
Daftar Isi:
- Solid dispersions of furosemide were prepared by melting and solvent methods using polyethylene glycol (PEG) 6000, talc and PEG – talc as dispersion carrier in order to improve furosemide dissolution. The increase of dissolution and physical properties of its powder was evaluated. Only furosemide solid dispersions with combination of PEG – talc 1 : 3 showed a good physical properties. The assay of the effect of PEG – talc ratio on furosemide dissolution showed that the increase of ratio of PEG – talc increased significantly dissolution rate.Key Word : furosemide, solid dispersion, dissolution