FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF DOMPERIDONE MALEATE
| Main Authors: | Dixit, Yuwaraj Dilipsingh; Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, (MS), India., Suruse, Pravin Babarao; Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, (MS), India., Shivhare, Umesh Dhaniram; Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur - 441 110, (MS), India. |
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| Format: | Article info eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2013
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/515 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/515/393 |
Daftar Isi:
- The objective of the present study was to develop and evaluate mucoadhesive dosage form of Domperidone maleate. It is an antiemetic synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. Mucoadhesive Domperidone maleate tablet formulation was prepared by direct compression method. The formulation F3 containing (Carbopol 940 + sodium alginate) was found to be best among all the formulation batches because of its consistent release rate for 7 h and extent of drug release was 94.44%. Graphical treatment of the formulation F3 to Higuchi’s equation showed that the drug release was diffusion mediated. In-vitro permeability study for formulation F3 for 7 h had shown 76.69% drug release. FTIR studies showed no evidence on interaction between drug and polymers. Key words: Domperidone maleate, Mucoadhesive tablet, antiemetic