Isolation of cytotoxic substance from Kaliapsis sponge
| Main Authors: | Setyowati, Erna Prawita; Faculty of Pharmacy, Universitas Gadjah Mada Sekip Utara Yogyakarta, 55281. Phone: 0274-542738, Jenie, Umar Anggara; Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta Indonesian Institute of Science, ., Sudarsono; Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta, Kardono, Broto; Indonesian Institute of Science, Rahmat, Rachmaniar; Indonesian Institute of Science, Meiyanto, Edy; Faculty of Pharmacy, Universitas Gadjah Mada Yogyakarta |
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| Format: | Article info eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2007
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| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/461 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/461/340 |
Daftar Isi:
- An isolation of cytotoxic substance of Kaliapsis sponge has been conducted. The substance was isolated using maceration, partition, vacuum liquid chromatography and preparative thin layer chromatograpy methods.The result of research showed that peak 1 has the most cytotoxic activity. Cytotoxicity test with MTT [3 (4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromide] reagen on myeloma cell showed that the peak 1 had a high activity against myeloma cell. It has IC50 equal to 0,18 μg/mL.Key word: Kaliapsis sponge, cytotoxic, myeloma cell