Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System
| Main Authors: | Astuti, Ika Yuni; Universitas Muhammadiyah Purwokerto, Marchaban, Marchaban; Universitas Gadjah Mada, Martien, Ronny; Universitas Gadjah Mada, Nugroho, Agung Endro; Universitas Gadjah Mada |
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| Format: | Article info application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia
, 2018
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| Subjects: | |
| Online Access: |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1285 http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1285/871 |
Daftar Isi:
- The recent work focuses on the physical characterization and dissolution study of PGV-0 loaded self-nanoemulsifying drug delivery system (SNEDDS). The PGV-0 SNEDDS was prepared by spontaneous emulsification method using oleic acid, tween 20:labrasol (1:1) and polyethylene glycol 400. The zeta potential of the PGV-0 SNEDDS was -34.4 ± 7.66 mv. The nanoemulsion of PGV-0 SNEDDS was thermodynamically stable with forming droplet oil containing PGV-0 in it and spherical. The dissolution result showed that the PGV-0 SNEDDS was able to increase the dissolution significantly (p <0.05) compared with PGV-0 powder of 44.13% in AGF medium and 30.37% in AIF medium. It is concluded that SNEDDS PGV-0 was able to increase the PGV-0 aqueous solubility.