Dynamics of Human Mesenchymal Stem Cells, M1 Microglia/Macrophage, and Fractalkine in Ischemic Stroke Patients
| Main Authors: | Herminawati, Lucia; Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia, Wijaya, Andi; Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia Prodia Clinical Laboratory, Indonesia Prodia Diagnostic Line, Indonesia, Arief, Mansyur; Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia, As’ad, Suryani; Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia |
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| Other Authors: | Postgraduate Program in Clinical Biochemistry, Hasanuddin University, Indonesia |
| Format: | Article application/pdf eJournal |
| Bahasa: | eng |
| Terbitan: |
BALI MEDICAL JOURNAL
, 2016
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| Subjects: | |
| Online Access: |
http://ojs.unud.ac.id/index.php/bmj/article/view/21792 |
Daftar Isi:
- Background: About 85% of strokes are ischemic strokes, caused by occlusion of cerebral artery that induced brain inflammation. A deep understanding of ischemic stroke mechanism will lead to better neurorestorative treatment. Objective: This study investigates the dynamics of human mesenchymal stem cells, fractalkine, and M1 microglia/macrophage in ischemic stroke patients. Results: We found the same fractalkine levels and M1 microglia/macrophage cells on patients with stroke onset 0 to 14 days, then decrease until 30 days of stroke onset. MSCs was increase 7 days after stroke onset, peaked by 14 days, then decreased until 30 days after stroke ischemic onset. Conclusions: This study found an interaction between microglia/macrophage, fractalkine, and MSCs on ischemic stroke patients, so therapeutic strategy could be developed.