obesity Development adipose tissue adults appetite body composition body fat distribution body weight regulation cardia cardiovascular disease risk factors computed tomography coronary artery disease [CAD] dietary composition and obesity dietary fat dietary intake eating disorders energy balance energy intake fat substitutes humans lipase inhibition lipids nutritional status obesity and eating disorders olestra orlistat racial differences sagittal diameter sucrose polyester triacyglycerol visceral adipose tissue waist circumference weight loss weight maintenance