Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.
| Main Authors: | Hadi Sunaryo, Hadi, Siska, Siska, Hanani, Endang, Anindita RS, Anindita, Yanti N, Yanti, Lisa, Lisa |
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| Format: | Article PeerReviewed Book |
| Bahasa: | eng |
| Terbitan: |
EUROPEAN PHARMACEUTICAL JOURNAL
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| Subjects: | |
| Online Access: |
http://repository.uhamka.ac.id/876/1/%5B24536725%20-%20European%20Pharmaceutical%20Journal%5D%20Evaluation%20of%20analgesic%20and%20anti-inflammatory%20activities%20of%20ethanolic%20extract%20of%20Cordia%20sebestena%20L..pdf http://repository.uhamka.ac.id/876/ |
Daftar Isi:
- Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats. The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract (100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and clinical settings.