ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITIES OF ETHYL ACETATE LEAF EXTRACT OF Icacinia trichantha ON PARACETAMOL-INDUCED LIVER DAMAGE IN RATS
| Main Authors: | Udeh, Nkeiruka E., Nwaehujor, Chinaka O. |
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| Format: | Article Journal |
| Terbitan: |
, 2011
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| Subjects: | |
| Online Access: |
https://zenodo.org/record/818042 |
Daftar Isi:
- Studies were conducted on the in vitro anti-oxidant and in vivo hepatoprotective effects of ethyl acetate extract of Icacinia trichantha leaves. Mature Wistar rats weighing 150-200 g were used to study the changes in alanine aminotransaminase (ALT), aspartate aminotranferase (AST), alkaline phosphatase (ALP), bilirubin and protein on paracetamol-induced liver damage in rats. In vitro anti-oxidant assays carried out include 1, 1-Diphenynl-2-Picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) Assays. Results showed that I. trichantha leaf extract at the dose of 400 mg/kg was able to reverse paracetamol induced hepatic damage better than silymarin (P<0.05). It also had positive anti-oxidant activities which were not favorably comparable to that of ascorbic acid (standard drug).